β-Amyloid (1-16)

β-Amyloid (1-16) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

Product Specifications

CAS Number

[131580-10-4]

Product Name Alternative

Amyloid β-Protein (1-16)

UNSPSC

12352209

Target

Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_beta_-Amyloid_1-16.html

Purity

99.98

Solubility

10 mM in H2O

Smiles

OC(C=C1)=CC=C1C[C@H](NC(CNC([C@H](CO)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@@H](N)CC(O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)CCCCN)=O)=O)CC5=CN=CN5)=O)=O)=O)=O

Molecular Formula

C84H119N27O28

Molecular Weight

1955.01

References & Citations

[1]Kowalik-Jankowska T, et al. Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper (II) ions: a combined potentiometric and spectroscopic study. J Inorg Biochem. 2003 Jul 1;95 (4) :270-82.|[2]Minicozzi V, et al. Identifying the minimal copper- and zinc-binding site sequence in amyloid-beta peptides. J Biol Chem. 2008 Apr 18;283 (16) :10784-92.|[3]Istrate AN, et al. NMR solution structure of rat aβ (1-16) : toward understanding the mechanism of rats' resistance to Alzheimer's disease. Biophys J. 2012 Jan 4;102 (1) :136-43.