ZW4864
Product Specifications
UNSPSC Description
ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM[1].
Target Antigen
β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zw4864.html
Purity
97.09
Solubility
DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(N(CC1=CC=C(C=C1)C2=CNN=C2)C3CC3)[C@H]4CN(CCC4)C5=CC=CC(OC(C)(C(N6CC[NH2+]CC6)=O)C)=C5.[Cl-]
Molecular Weight
607.19
References & Citations
[1]Wang Z, et al. Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction. J Med Chem. 2021;64(16):12109-12131.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132300/ZW4864-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132300/ZW4864-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2632259-93-7
Available Sizes
Curated Selection
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