Dasotraline (hydrochloride)
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
Product Specifications
CAS Number
675126-08-6
Product Name Alternative
SEP-225289 hydrochloride
UNSPSC
12352005
Target
Dopamine Transporter; Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Dasotraline__hydrochloride_.html
Purity
99.04
Solubility
DMSO : ≥ 31 mg/mL|H2O : 1.61 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N[C@@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=CC=CC=C31.Cl[H]
Molecular Formula
C16H16Cl3N
Molecular Weight
328.66
References & Citations
[1]Guiard BP, et al. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. Int J Neuropsychopharmacol. 2011 Mar;14 (2) :211-23.|[2]DeLorenzo C, et al. SEP-225289 serotonin and dopamine transporter occupancy: a PET study.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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