Dasotraline (hydrochloride)

Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.

Product Specifications

CAS Number

[675126-08-6]

Product Name Alternative

SEP-225289 hydrochloride

UNSPSC

12352005

Target

Dopamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Dasotraline__hydrochloride_.html

Purity

99.04

Solubility

DMSO : ≥ 31 mg/mL|H2O : 1.61 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N[C@@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=CC=CC=C31.Cl[H]

Molecular Formula

C16H16Cl3N

Molecular Weight

328.66

References & Citations

[1]Guiard BP, et al. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. Int J Neuropsychopharmacol. 2011 Mar;14 (2) :211-23.|[2]DeLorenzo C, et al. SEP-225289 serotonin and dopamine transporter occupancy: a PET study.