4-Hydroxyphenylacetic acid-d4
4-Hydroxyphenylacetic acid-d4 is the deuterium labeled 4-Hydroxyphenylacetic acid[1]. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[2].
Product Specifications
UNSPSC
12352005
Target
Endogenous Metabolite; Keap1-Nrf2
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
O=C(O)C([2H])(C1=CC([2H])=C(O)C([2H])=C1)[2H]
Molecular Formula
C8H4D4O3
Molecular Weight
156.17
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Zhao H, et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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