GAD65 (524-543)

GAD65 (524-543) is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65) . GAD65 (524-543) is one of the first fragments of islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells[1].

Product Specifications

CAS Number

[152468-44-5]

UNSPSC

12352209

Target

Amino Acid Decarboxylase

Type

Peptides

Related Pathways

Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/gad65-524-543.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H]([C@H](O)C)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H]2N(CCC2)C([C@H](C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CO)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C97H168N28O28S2

Molecular Weight

2238.67

References & Citations

[1]Dai YD, et al. A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas. J Immunol. 2005 Sep 15;175 (6) :3621-7.