HPK1-IN-48
Product Specifications
UNSPSC Description
HPK1-IN-48 (compound 14g) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a IC50 of 0.15 nM. HPK1-IN-48 significantly suppresses the phosphorylation of SLP76 with a IC50 of 27.92 nM[1].
Target Antigen
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-48.html
Smiles
COC1=C(C=CC(N2CC(N(C(C2)C)C)C)=C1)NC3=C(C=NC(NC4=CC=C(C=C4)C(NCC5=CC=CC=C5)=O)=N3)C(N)=O
Molecular Weight
594.71
References & Citations
[1]Fu S, et al. Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine derivatives as potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors. Bioorg Chem. 2024 Jul;148:107454.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163717/HPK1-IN-48-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163717/
Clinical Information
No Development Reported
Curated Selection
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