HPK1-IN-48

HPK1-IN-48 (compound 14g) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a IC50 of 0.15 nM. HPK1-IN-48 significantly suppresses the phosphorylation of SLP76 with a IC50 of 27.92 nM[1].

Product Specifications

UNSPSC

12352005

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hpk1-in-48.html

Smiles

COC1=C(C=CC(N2CC(N(C(C2)C)C)C)=C1)NC3=C(C=NC(NC4=CC=C(C=C4)C(NCC5=CC=CC=C5)=O)=N3)C(N)=O

Molecular Formula

C33H38N8O3

Molecular Weight

594.71

References & Citations

[1]Fu S, et al. Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine derivatives as potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors. Bioorg Chem. 2024 Jul;148:107454.