Baclofen

Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3].

Product Specifications

CAS Number

[1134-47-0]

UNSPSC

12352005

Hazard Statement

H301

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Baclofen.html

Purity

99.98

Solubility

0.1 M HCl : 10 mg/mL (ultrasonic) |DMSO : 4.76 mg/mL (ultrasonic; warming; adjust pH to 4 with 1 M HCL; heat to 60°C) |H2O : 2 mg/mL (ultrasonic)

Smiles

O=C(O)CC(C1=CC=C(Cl)C=C1)CN

Molecular Formula

C10H12ClNO2

Molecular Weight

213.66

Precautions

H301

References & Citations

[1]Bexis, S., et al., Baclofen prevents MDMA-induced rise in core body temperature in rats. Drug Alcohol Depend, 2004. 74 (1) : p. 89-96.|[2]Mehdi Farokhnia, et al. A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation. Mol Psychiatry. 2018 Oct 31.|[3]Woori Kim, et al. Baclofen, a GABAB receptor agonist, enhances ubiquitin-proteasome system functioning and neuronal survival in Huntington's disease model mice. Biochem Biophys Res Commun. 2014 Jan 10;443 (2) :706-11.