Dicyclomine (hydrochloride)

Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].

Product Specifications

CAS Number

[67-92-5]

Product Name Alternative

Dicycloverine (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dicyclomine-hydrochloride.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(C1(C2CCCCC2)CCCCC1)OCCN(CC)CC.[H]Cl

Molecular Formula

C19H36ClNO2

Molecular Weight

345.95

Precautions

H302, H315, H319, H335

References & Citations

[1]J Pavía, et al. Pharmacological Characterization and Distribution of Muscarinic Receptors in Human Placental Syncytiotrophoblast Brush-Border and Basal Plasma Membranes. Eur J Pharmacol. . 1997 Feb 12;320 (2-3) :209-14.|[2]Antonella Caccamo, et al. M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice. 2006 Mar 2;49 (5) :671-82.doi: 10.1016/j.neuron.2006.01.020.|[3]Susan J Bartko, et al. A Computer-Automated Touchscreen Paired-Associates Learning (PAL) Task for Mice: Impairments Following Administration of Scopolamine or Dicyclomine and Improvements Following Donepezil.Psychopharmacology (Berl) . 2011 Mar;214 (2) :537-48.