CYD19
CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis[1].
Product Specifications
CAS Number
2415281-52-4
Product Name Alternative
Snail/HDAC-IN-1
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyd19.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(F)C=C1N)C2=CC=C(CSC(N=C3NC4=NNC(C)=C4)=NN5C3=CC=C5)C=C2
Molecular Formula
C24H21FN8OS
Molecular Weight
488.54
References & Citations
[1]Cui H, et al. Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer. Eur J Med Chem. 2022;229:114082.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1
Available Sizes
Frequently Asked Questions
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