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15-A2t-Isoprostane

15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid[1][2][3].

Product Specifications

CAS Number

474391-66-7

Product Name Alternative

8-iso Prostaglandin A2

UNSPSC

12352211

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/15-a2t-isoprostane.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@H]([C@H](C=C1)/C=C/[C@H](CCCCC)O)C/C=C\CCCC(O)=O

Molecular Formula

C20H30O4

Molecular Weight

334.45

References & Citations

[1]Chen Y, et al. Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. J Biol Chem. 1999 Apr 16;274 (16) :10863-8.|[2]Musiek ES, et al. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J Neurochem. 2006 Jun;97 (5) :1301-13.|[3]Benndorf RA, et al. Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A (2) receptor: a potential link between oxidative stress and impaired angiogenesis. Circ Res. 2008 Oct 24;103 (9) :1037-46.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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