15-A2t-Isoprostane
15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid[1][2][3].
Product Specifications
CAS Number
474391-66-7
Product Name Alternative
8-iso Prostaglandin A2
UNSPSC
12352211
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/15-a2t-isoprostane.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@H]([C@H](C=C1)/C=C/[C@H](CCCCC)O)C/C=C\CCCC(O)=O
Molecular Formula
C20H30O4
Molecular Weight
334.45
References & Citations
[1]Chen Y, et al. Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. J Biol Chem. 1999 Apr 16;274 (16) :10863-8.|[2]Musiek ES, et al. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J Neurochem. 2006 Jun;97 (5) :1301-13.|[3]Benndorf RA, et al. Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A (2) receptor: a potential link between oxidative stress and impaired angiogenesis. Circ Res. 2008 Oct 24;103 (9) :1037-46.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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