GSK2982772
GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively[1].
Product Specifications
CAS Number
[1622848-92-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/GSK2982772.html
Purity
99.79
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC(CC2=CC=CC=C2)=NN1)N[C@H]3COC4=CC=CC=C4N(C)C3=O
Molecular Formula
C20H19N5O3
Molecular Weight
377.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Harris PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J Med Chem. 2017 Feb 23;60 (4) :1247-1261.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
131703 50 µg
PPP1R3B (PPP1R4, Protein Phosphatase 1 Regulatory Subunit 3B, Hepatic Glycogen-targeting Protein Phosphatase 1 Regulatory Subunit GL, Protein Phosphatase 1 Regulatory Subunit 4, Protein Phosphatase 1 Subunit GL)
Ask
View Details 