Gallic acid

Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) [1]. Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2].

Product Specifications

CAS Number

[149-91-7]

Product Name Alternative

3,4,5-Trihydroxybenzoic acid

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; COX; Endogenous Metabolite; Ferroptosis; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Gallic_acid.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : ≥ 100 mg/mL|H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C1=CC(O)=C(O)C(O)=C1

Molecular Formula

C7H6O5

Molecular Weight

170.12

Precautions

H315, H319, H335

References & Citations

[1]Amaravani M, et al. COX-2 structural analysis and docking studies with gallic acid structural analogues. Springerplus. 2012 Dec;1 (1) :58.|[2]Bak EJ, et al. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013 Dec;73 (8) :607-14.|[3]Cheng Y, et al. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase? Oxid Med Cell Longev. 2015;2015:434052.