TBK1-IN-1
TBK1-IN-1 is a potent and selective TANK binding kinase 1 (TBK1) inhibitor with an IC50 value of 22.4 nM. TBK1-IN-1 inhibits TBK1 downstream target genes cxcl10 and ifnβ expression. TBK1-IN-1 has anticancer activity[1].
Product Specifications
UNSPSC
12352005
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tbk1-in-1.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1CCN(CC1)CC2=CC=CC(NC3=NC=C4C=CN(C4=N3)CCCNC(C5CCC5)=O)=C2)=O
Molecular Formula
C27H35N7O2
Molecular Weight
489.61
References & Citations
[1]Song S, et al. Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors. Eur J Med Chem. 2023 Feb 5;247:115034.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TBK1
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
K1788906 1.0 µg DNA
RASGRP3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
Sign In for Pricing
View Details TL701923V 500 µL Each
Jpt2 Rat shRNA Lentiviral Particle (Locus ID 360492)
Sign In for Pricing
View Details 
244238-PE 100 µL
CASP10 (Caspase 10, Apoptosis-Related Cysteine Peptidase, ALPS2, FLICE2, MCH4) (PE)
Sign In for Pricing
View Details NBP2-98271CL1 0.1 mL
Rabbit Polyclonal Glyoxalase I Antibody [CoraFluor 1]
Sign In for Pricing
View Details