MSU38225

MSU38225 is an Nrf-2 inhibitor that increases levels of reactive oxygen species (ROS) . MSU38225 inhibits the growth of human lung cancer cells and enhances the sensitivity of human lung cancer cells to chemotherapy in vitro and in vivo. MSU38225 can be used in cancer research[1].

Product Specifications

CAS Number

[1629160-83-3]

UNSPSC

12352005

Target

Keap1-Nrf2; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/msu38225.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=C(NC2=CC(C)=CC(C)=C2)N=C(C)C(C3=CC=CC=C3)=C1

Molecular Formula

C21H19N3

Molecular Weight

313.40

References & Citations

[1]Zhang D, et al. A Novel Nrf2 Pathway Inhibitor Sensitizes Keap1-Mutant Lung Cancer Cells to Chemotherapy. Mol Cancer Ther. 2021 Sep;20 (9) :1692-1701.