6PGD-IN-1
6PGD-IN-1 (compound S3) is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD) . IC50 and Kd the value of 17.8μM and 17.1 μM respectively. 6PGD-IN-1 has antitumor activity[1].
Product Specifications
CAS Number
[5539-66-2]
Product Name Alternative
1-Hydroxy-8-methoxyanthraquinone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6pgd-in-1.html
Purity
99.48
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=CC=C2OC)C(C3=CC=CC(O)=C13)=O
Molecular Formula
C15H10O4
Molecular Weight
254.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17 (11) :1484-96.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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