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P38-α MAPK-IN-1

P38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay[1].

Product Specifications

CAS Number

[443913-15-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Autophagy; p38 MAPK

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/p38-_alpha__MAPK-IN-1.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(N2C(NC(NC3=CC=C(OCCN4CCOCC4)C=C3)=O)=CC(C(C)(C)C)=N2)C=C1

Molecular Formula

C27H35N5O3

Molecular Weight

477.60

Precautions

H302, H315, H319

References & Citations

[1]Kluter S, et al. Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem. 2010 Jan 14;53 (1) :357-67.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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