P38-α MAPK-IN-1
P38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay[1].
Product Specifications
CAS Number
[443913-15-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Autophagy; p38 MAPK
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/p38-_alpha__MAPK-IN-1.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=C(N2C(NC(NC3=CC=C(OCCN4CCOCC4)C=C3)=O)=CC(C(C)(C)C)=N2)C=C1
Molecular Formula
C27H35N5O3
Molecular Weight
477.60
Precautions
H302, H315, H319
References & Citations
[1]Kluter S, et al. Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem. 2010 Jan 14;53 (1) :357-67.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6347719-01 0.1 mL
SIM1, NT (SIM1, BHLHE14, Single-minded homolog 1, Class E basic helix-loop-helix protein 14) (MaxLight 405)
Ask
View Details 
MBS6347719-02 5x 0.1 mL
SIM1, NT (SIM1, BHLHE14, Single-minded homolog 1, Class E basic helix-loop-helix protein 14) (MaxLight 405)
Ask
View Details