METTL3-IN-8
METTL3-IN-8 (F039-0002) is a potent METTL3 inhibitor. METTL3-IN-8 strongly ameliorates Dextran sulfate sodium salt (DSS) (HY-116282C) -induced colitis. METTL3-IN-8 can be used Inflammatory bowel disease (IBD) research[1].
Product Specifications
CAS Number
[932512-38-4]
UNSPSC
12352005
Target
METTL3
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mettl3-in-8.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=CC(NC(NC2=CNC(NC2=O)=O)=O)=C1
Molecular Formula
C12H12N4O4
Molecular Weight
276.25
References & Citations
[1]Yin H, et al. Inhibition of METTL3 in macrophages provides protection against intestinal inflammation. Cell Mol Immunol. 2024 Jun;21 (6) :589-603.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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