Anandamide

Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2) . Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis[1][2][3][4][5].

Product Specifications

CAS Number

[94421-68-8]

Product Name Alternative

AEA; Arachidonoyl ethanolamide

UNSPSC

12352211

Hazard Statement

H314

Target

Cannabinoid Receptor; Endogenous Metabolite; Fungal; GPR55; PPAR; Tau Protein; TRP Channel

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5,8,11,14-Eicosatetraenamide,_N-_2-hydroxyethyl_-,__5Z,8Z,11Z,14Z_-.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(NCCO)=O

Molecular Formula

C22H37NO2

Molecular Weight

347.53

Precautions

H314

References & Citations

[1]Malek N, et al. Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures. Neural Plast. 2015;2015:130639.|[2]Troy-Fioramonti S, et al. Acute activation of cannabinoid receptors by Anandamide reduces gastrointestinal motility and improves postprandial glycemia in mice. Diabetes. 2015 Mar;64 (3) :808-18.|[3]Moreira-Silva D, et al. Anandamide Effects in a Streptozotocin-Induced Alzheimer's Disease-Like Sporadic Dementia in Rats. Front Neurosci. 2018 Sep 21;12:653.|[4]Sionov RV, et al. Anandamide prevents the adhesion of filamentous Candida albicans to cervical epithelial cells. Sci Rep. 2020 Aug 13;10 (1) :13728.|[5]Pflüger-Müller B, et al. The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells. Basic Res Cardiol. 2020 Apr 22;115 (3) :34.