Pirenzepine (dihydrochloride)
Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells[1][2].
Product Specifications
CAS Number
29868-97-1
Product Name Alternative
LS 519; Pirenzepin (dihydrochloride) ; Gastrozepin (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Pirenzepine_dihydrochloride.html
Concentration
10mM
Purity
99.93
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=CN=C2N(C(CN3CCN(C)CC3)=O)C4=CC=CC=C14.[H]Cl.[H]Cl
Molecular Formula
C19H23Cl2N5O2
Molecular Weight
424.32
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR1
Citation 01
Cell Rep. 2025 Apr 16;44 (5) :115572.|Research Square Preprint. 2021 Jan.|Mol Cell Endocrinol. 2025 Jan 21:599:112464.
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