(E/Z) -Icerguastat

(E/Z) -Icerguastat ((E/Z) -Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A) . (E/Z) -Icerguastat can be used for protein misfolding diseases research[1].

Product Specifications

CAS Number

[13098-73-2]

Product Name Alternative

(E/Z) -Sephin1; (E/Z) -IFB-088

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/e-z-icerguastat.html

Concentration

10mM

Purity

99.44

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=CC=C1/C=N/NC(N)=N

Molecular Formula

C8H9ClN4

Molecular Weight

196.64

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015 Apr 10;348 (6231) :239-42.