Nonapeptide-1 (acetate salt)

Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM) . Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively) . Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer[1][2][3].

Product Specifications

Product Name Alternative

Melanostatine-5 (acetate salt)

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Nonapeptide-1_acetate_salt.html

Purity

95.58

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H](N)CCSC)N1[C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N)=O)C(C)C)=O)CCC2)=O)CCCCN)=O)CC3=CC=CC=C3)=O)CC4=CNC5=CC=CC=C45)=O)CCCNC(N)=N)=O)CC6=CC=CC=C6)=O)CCC1.CC(O)=O

Molecular Formula

C63H91N15O11S

Molecular Weight

1266.56

References & Citations

[1]Jayawickreme CK, et al. Discovery and structure-function analysis of alpha-melanocyte-stimulating hormone antagonists. J Biol Chem. 1994 Nov 25;269 (47) :29846-54.|[2][2] Schiöth, H.B., et al. Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 (6), 565-571 (1997) . |[3]Jiaoquan Chen, et al. Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. Postepy Dermatol Alergol. 2022 Apr;39 (2) :327-335.