PX-866-17OH
PX-866-17OH is the metabolite of PX-866 (Sonolisib, HY-N6775) and a pan-isoform inhibitor of PI3K with IC50s of 14, 57, 131, and 148 nM against PI3Kα, PI3Kβ, PI3K , and PI3Kδ, respectively[1].
Product Specifications
CAS Number
[1012327-63-7]
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/px-866-17oh.html
Smiles
C[C@@]12C3=C(C(C(O)=C1/C(C(O[C@@H]2COC)=O)=C\N(CC=C)CC=C)=O)[C@@]4([H])[C@](C[C@H]3OC(C)=O)([C@H](CC4)O)C
Molecular Formula
C29H37NO8
Molecular Weight
527.61
References & Citations
[1]Zask A, et al. Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51 (5) :1319-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15300915 1 Vial
Lentiviral mouse Gtpbp3 shRNA (UAS) - Lentiviral mouse Gtpbp3 shRNA (UAS, RFP) (100)
Sign In for Pricing
View Details 
![Rabbit anti-Rotavirus A (strain RVA/Cow/Canada/C486/1977/G6P6[1])(RV-A) Outer capsid glycoprotein VP7 Polyclonal Antibody](https://cdn.genprice.uk/genprice/uk/genprice3.webp)
MBS7168884-01 0.05 mL
Rabbit anti-Rotavirus A (strain RVA/Cow/Canada/C486/1977/G6P6[1])(RV-A) Outer capsid glycoprotein VP7 Polyclonal Antibody
Sign In for Pricing
View Details MBS7168884-02 0.1 mL
Rabbit anti-Rotavirus A (strain RVA/Cow/Canada/C486/1977/G6P6[1])(RV-A) Outer capsid glycoprotein VP7 Polyclonal Antibody
Sign In for Pricing
View Details MBS7168884-03 5x 0.1 mL
Rabbit anti-Rotavirus A (strain RVA/Cow/Canada/C486/1977/G6P6[1])(RV-A) Outer capsid glycoprotein VP7 Polyclonal Antibody
Sign In for Pricing
View Details