PX-866-17OH

PX-866-17OH is the metabolite of PX-866 (Sonolisib, HY-N6775) and a pan-isoform inhibitor of PI3K with IC50s of 14, 57, 131, and 148 nM against PI3Kα, PI3Kβ, PI3K , and PI3Kδ, respectively[1].

Product Specifications

CAS Number

[1012327-63-7]

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/px-866-17oh.html

Smiles

C[C@@]12C3=C(C(C(O)=C1/C(C(O[C@@H]2COC)=O)=C\N(CC=C)CC=C)=O)[C@@]4([H])[C@](C[C@H]3OC(C)=O)([C@H](CC4)O)C

Molecular Formula

C29H37NO8

Molecular Weight

527.61

References & Citations

[1]Zask A, et al. Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51 (5) :1319-23.