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Anti-ROR2 Antibody

Mouse Monoclonal Antibody specific to ROR2

Product Specifications

Product Name Alternative

EC 2.7.10.1, Neurotrophic tyrosine kinase, receptor-related 2

Gene Name

ROR2

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=ROR2">ROR2</a>

UniProt

Q01974

Cellular Locus

Cell membrane, Single-pass type I membrane protein

Host

Mouse

Reactivity

Human, Mouse

Immunogen

Bases 2535-2835 of mouse ROR2 fused in-frame to MBP and expressed in E. coli.

Target Antigen

Tyrosine-protein kinase transmembrane receptor ROR2

Target

ROR2

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, IHC

Field of Research

Cancer research

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {UniProtKB:Q9Z138, PubMed:17717073, PubMed:25029443}.

Additionnal Information

Immunoblotting: use at 1-10ug/mL. A band of ~105kDa is detected. <br><br>Immunohistochemistry: use at 1-10ug/mL on paraformaldehyde-fixed, paraffin-embedded sections following antigen retrieval (microwave 12 min in citrate buffer, pH 6.0). <br><br>These are recommended concentrations. <br><br>Enduser should determine optimal concentrations for their application.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/34045.pdf

Specificity

Mouse and human ROR2. Does not cross-react with ROR1.

Formulation

PBS, pH 7.4.Purified by Protein G affinity chromatography.

Buffer pH

pH 7.4

Target Background

Receptor tyrosine kinases (RTKs) are cell surface receptors that regulate normal cellular processes through ligand-controlled tyrosine kinase activity. ROR2 is a membrane-bound RTK that is activated by Wnt signaling during normal bone and cartilage development. Recently, ROR2 has been shown to have pro-tumorigenic effects in osteosarcoma, melanoma, and renal cell carcinoma cell lines. ROR2 levels have also been described in soft-tissue sarcomas; specifically, in vitro studies revealed that invasive abilities of leiomyosarcoma (LMS) and gastrointestinal stromal tumor (GIST) are affected by ROR2 expression, and suppression of ROR2 reduces in vivo tumor mass in a xenotransplantation model of LMS.

CAS Number

9007-83-4

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