MD2-TLR4-IN-1

MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. MD2-TLR4-IN-1 inhibits Lipopolysaccharides (HY-D1056) (LPS) -induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 can be used for the study of acute lung injury (ALI) [1].

Product Specifications

CAS Number

[2249801-12-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/md2-tlr4-in-1.html

Purity

98.16

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

ClC1=C(C(NC2=CC(C(C3=CC=C(NC=C4)C4=C3)=NN5)=C5C=C2)=O)C(Cl)=CC=C1

Molecular Formula

C22H14Cl2N4O

Molecular Weight

421.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Liu Z, et al. Discovery of 3- (Indol-5-yl) -indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62 (11) :5453-5469.