R121919

R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats[1][2][3].

Product Specifications

CAS Number

[195055-03-9]

Product Name Alternative

NBI30775

UNSPSC

12352005

Target

CRFR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/R121919.html

Purity

99.66

Solubility

DMSO : 6.2 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

CCCN(C1=CC(C)=NC2=C(C3=CN=C(N(C)C)C=C3C)C(C)=NN21)CCC

Molecular Formula

C22H32N6

Molecular Weight

380.53

References & Citations

[1]Gutman DA, et al. The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. J Pharmacol Exp Ther. 2003 Feb;304 (2) :874-80.|[2]Post A, et al. Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919) . Psychopharmacology (Berl) . 2005 Jun;180 (1) :150-8.|[3]Gutman DA, et al. Behavioral effects of the CRF1 recepator antagonist R121919 in rats selectively bred for high and low activity in the swim test. Psychoneuroendocrinology. 2008 Sep;33 (8) :1093-101.