(+) -Usnic acid

(+) -Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+) -Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer and anti-inflammatory activity. (+) -Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium[1][2][3].

Product Specifications

CAS Number

[7562-61-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Bacterial; mTOR

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/usnic-acid.html

Purity

99.63

Solubility

DMSO : ≥ 1.92 mg/mL|H2O : < 0.1 mg/mL

Smiles

O=C([C@@]1(C)C(OC2=C(C(C)=O)C(O)=C(C)C(O)=C12)=C3)C(C(C)=O)C3=O

Molecular Formula

C18H16O7

Molecular Weight

344.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Ebrahim HY, et al. Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies. J Nat Prod. 2017 Apr 28;80 (4) :932-952.|[2]Francolini I, et al. Usnic acid, a natural antimicrobial agent able to inhibit bacterial biofilm formation on polymer surfaces. Antimicrob Agents Chemother. 2004;48 (11) :4360-4365.|[3]Vijayakumar CS, et al. Anti-inflammatory activity of (+) -usnic acid. Fitoterapia. 2000 Sep;71 (5) :564-6.