Mongersen (sodium)

Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice[1][2].

Product Specifications

CAS Number

[1443994-98-6]

Product Name Alternative

GED-0301 (sodium)

UNSPSC

12352208

Target

TGF-beta/Smad

Type

Oligonucleotides

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mongersen-sodium.html

Purity

99.61

Solubility

H2O : ≥ 100 mg/mL

Smiles

[Mongersen(sodium)]

Molecular Formula

C200H241N69O107P20S20Na20

Molecular Weight

6604 (free acid)

References & Citations

[1]Monteleone G, et, al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015 Mar 19;372 (12) :1104-13.|[2]Izzo R, et, al. Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice. Inflamm Bowel Dis. 2018 May 18;24 (6) :1213-1224.