Mongersen (sodium)
Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice[1][2].
Product Specifications
CAS Number
1443994-98-6
Product Name Alternative
GED-0301 (sodium)
UNSPSC
12352208
Target
TGF-beta/Smad
Type
Oligonucleotides
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mongersen-sodium.html
Purity
99.61
Solubility
H2O : ≥ 100 mg/mL
Smiles
[Mongersen(sodium)]
Molecular Formula
C200H241N69O107P20S20Na20
Molecular Weight
6604 (free acid)
References & Citations
[1]Monteleone G, et, al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015 Mar 19;372 (12) :1104-13.|[2]Izzo R, et, al. Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice. Inflamm Bowel Dis. 2018 May 18;24 (6) :1213-1224.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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