Mongersen (sodium)
Product Specifications
UNSPSC Description
Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice[1][2].
Target Antigen
TGF-beta/Smad
Type
Oligonucleotides
Related Pathways
Stem Cell/Wnt;TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mongersen-sodium.html
Solubility
H2O : ≥ 100 mg/mL
Smiles
[Mongersen (sodium)]
Molecular Weight
7044.00
References & Citations
[1]Monteleone G, et, al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. N Engl J Med. 2015 Mar 19;372(12):1104-13.|[2]Izzo R, et, al. Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice. Inflamm Bowel Dis. 2018 May 18;24(6):1213-1224.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145721A/Mongersen-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145721A/Mongersen-sodium-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
1443994-98-6
Available Sizes
Curated Selection
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