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eIF4A3-IN-2

Product Specifications

UNSPSC Description

eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM[1].

Target Antigen

Autophagy; Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Autophagy;Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/eIF4A3-IN-2.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(Br)C=C1)N2CCN(C(C3=C4N(C=C(Br)C=C4)N=C3)=O)C[C@@H]2C5=CC=C(Cl)C=C5

Molecular Weight

602.70

References & Citations

[1]Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017 Jul 21;12(7):1760-1768.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101785/eIF4A3-IN-2-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101785/eIF4A3-IN-2-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2095677-20-4

Available Sizes

Curated Selection

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