ROS-ERS inducer 1
ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt (II) -N-heterocyclic carbene (Pt (II) -NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin[1].
Product Specifications
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ros-ers-inducer-1.html
Concentration
10mM
Purity
99.12
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
FC(C=C1)=CC=C1c2c(C3=CC=C(F)C=C3)n(CC)c([Pt]([N]4=CC=CC=C4)(I)I)n2CC
Molecular Formula
C24H23F2I2N3Pt
Molecular Weight
840.35
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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