Se-Methylselenocysteine

Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis[1][2].

Product Specifications

CAS Number

[26046-90-2]

Product Name Alternative

Methylselenocysteine; Se-Methylseleno-L-cysteine

UNSPSC

12352211

Hazard Statement

H301, H331, H373, H410

Target

Apoptosis; Beta-secretase; Endogenous Metabolite

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/se-methylselenocysteine.html

Purity

99.60

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 62.5 mg/mL (ultrasonic)

Smiles

OC([C@@H](N)C[Se]C)=O

Molecular Formula

C4H9NO2Se

Molecular Weight

182.08

Precautions

H301, H331, H373, H410

References & Citations

[1]Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182 (1) :83-92.|[2]Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110 (7) :1733-43.|[3]Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62 (12) :e1800107.