SSR504734

SSR504734 is an orally active, selective and reversible inhibitor of human, rat, and mouse GlyT1 (IC50=18, 15, and 38 nM, respectively) . SSR504734 shows anti-schizophrenia, anti-anxiety and anti-depression activities[1].

Product Specifications

CAS Number

[615571-23-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ssr504734.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C(C(F)(F)F)=CC=C1)Cl)N[C@H]([C@]2([H])CCCCN2)C3=CC=CC=C3.Cl

Molecular Formula

C20H21Cl2F3N2O

Molecular Weight

433.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Ronan Depoortère, et al. Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology. 2005 Nov;30 (11) :1963-85.