DB2115 (tertahydrochloride)
DB2115 tetrahydrochloride is a highly selective PU.1 inhibitor that suppresses the binding of PU.1 to DNA (IC50: 2.3 nM) . DB2115 tetrahydrochloride can inhibit tumor cell proliferation and induce apoptosis. DB2115 tetrahydrochloride can be used in the research of tumors such as leukemia[1].
Product Specifications
CAS Number
[1366126-19-3]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db2115-tertahydrochloride.html
Purity
99.13
Solubility
DMSO : 15.85 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)
Smiles
N=C(C1=CC=C2N=C(C3=CC=C(OCCCCOC4=CC=C(C5=NC6=CC=C(C(N)=N)C=C6N5)C=C4)C=C3)NC2=C1)N.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C32H34Cl4N8O2
Molecular Weight
704.48
References & Citations
[1]W. David Wilson, et al. Pu.1 inhibitors. Patent WO2017223260A1. 2017-12-28.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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