DB2115 (tertahydrochloride)
DB2115 tetrahydrochloride is a highly selective PU.1 inhibitor that suppresses the binding of PU.1 to DNA (IC50: 2.3 nM) . DB2115 tetrahydrochloride can inhibit tumor cell proliferation and induce apoptosis. DB2115 tetrahydrochloride can be used in the research of tumors such as leukemia[1].
Product Specifications
CAS Number
[1366126-19-3]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db2115-tertahydrochloride.html
Purity
99.13
Solubility
DMSO : 15.85 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)
Smiles
N=C(C1=CC=C2N=C(C3=CC=C(OCCCCOC4=CC=C(C5=NC6=CC=C(C(N)=N)C=C6N5)C=C4)C=C3)NC2=C1)N.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Molecular Formula
C32H34Cl4N8O2
Molecular Weight
704.48
References & Citations
[1]W. David Wilson, et al. Pu.1 inhibitors. Patent WO2017223260A1. 2017-12-28.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Browse additional items from our catalog
Human Ankyrin Repeat Domain 33 (ANKRD33) ELISA Kit
Human Ankyrin Repeat Domain 33 (ANKRD33) ELISA Kit
Human Ankyrin Repeat Domain 33 (ANKRD33) ELISA Kit
HES2 (Transcription Factor HES-2, Class B Basic Helix-loop-helix Protein 40, bHLHb40, Hairy and Enhancer of Split 2, BHLHB40) (AP) discontinued