Psychosine-d5
Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell.
Product Specifications
CAS Number
2260670-12-8
Product Name Alternative
Galactosylsphingosine-d5
UNSPSC
12352005
Target
PKC
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Purity
99.0
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C([2H])([2H])CCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO[C@@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)CO
Molecular Formula
C24H42D5NO7
Molecular Weight
466.66
References & Citations
[1]M L Escolar, et al. Psychosine, a marker of Krabbe phenotype and treatment effect. Mol Genet Metab. 2017 Jul;121 (3) :271-278.|[2]Jacqueline A Hawkins-Salsbury, et al.Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. J Lipid Res.2013 Dec;54 (12) :3303-11.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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