Coumermycin A1

Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.

Product Specifications

CAS Number

[4434-05-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Bacterial; JAK; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/coumermycin-a1.html

Purity

99.86

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCl; heat to 60°C)

Smiles

OC(C1=CC=C(O[C@@H]([C@H](O)[C@H](OC(C2=CC=C(C)N2)=O)[C@H]3OC)OC3(C)C)C(C)=C1O4)=C(NC(C5=CNC(C(NC6=C(O)C7=CC=C(O[C@@H]([C@H](O)[C@H](OC(C8=CC=C(C)N8)=O)[C@H]9OC)OC9(C)C)C(C)=C7OC6=O)=O)=C5C)=O)C4=O

Molecular Formula

C55H59N5O20

Molecular Weight

1110.08

Precautions

H302

References & Citations

[1]Tiantian Zhang, et al. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. Research Article.|[2]Donald F Smee, et al. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother. 2008;19 (3) :115-24.