CCT373566
CCT373566 is a potent and orally active molecular glue degrader of transcriptional repressor BCL6, with an IC50 of 2.2 nM. CCT373566 shows strong antiproliferative efficacy in vitro and reduction in tumor growth in vivo[1].
Product Specifications
CAS Number
2378853-66-6
UNSPSC
12352005
Target
Bcl-2 Family; Molecular Glues
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cct373566.html
Purity
99.61
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N(C)C2=C(C=C(NC3=NC(N4C[C@H](O)C[C@H](C)C4)=NC=C3Cl)C=C2)C5=C1OCC(F)(F)[C@H](C6CC6)N5
Molecular Formula
C26H29ClF2N6O3
Molecular Weight
547.00
References & Citations
[1]Huckvale R, et, al. Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo. J Med Chem. 2022 Jun 23;65 (12) :8191-8207.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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