Tauro-α-muricholic acid-d4-1 (sodium)
Tauro-α-muricholic acid-d4-1 (sodium) is deuterium labeled Tauro-α-muricholic acid (sodium) . Tauro-α-muricholic acid (T-α-MCA) sodium is a FXR (Farnesoid X receptor) antagonist (IC50=28μM) . Tauro-α-muricholic acid sodium is also a endogenous metabolite that can be found in cecal[1][2][3].
Product Specifications
Product Name Alternative
T-α-MCA-d4-1 (sodium)
UNSPSC
12352211
Target
Endogenous Metabolite; FXR; Isotope-Labeled Compounds
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Others
Smiles
C[C@@H]([C@H]1CC[C@]2([C@@]3([C@@H]([C@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)O)[H])[H])CCC(NC([2H])([2H])C([2H])([2H])S(=O)(O[Na])=O)=O
Molecular Formula
C26H40D4NNaO7S
Molecular Weight
541.71
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chen W, et al. Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect. Int J Med Sci. 2023 Apr 2;20 (5) :595-605.|[3]Ye X, et al. Sodium butyrate alleviates cholesterol gallstones by regulating bile acid metabolism. Eur J Pharmacol. 2021 Oct 5;908:174341.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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