LCS3
LCS3 is a reversible and uncompetitive glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) inhibitor (IC50=3.3 μM and 3.8 μM, respectively) . LCS3 shows anti-tumor activity, and induces apoptosis. LCS3 can be used in lung adenocarcinoma (LUAD) research[1].
Product Specifications
CAS Number
109844-92-0
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lcs3.html
Purity
99.43
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(Cl)C=C2
Molecular Formula
C11H7ClN2O4
Molecular Weight
266.64
Precautions
H315, H319, H320
References & Citations
[1]Fraser D Johnson, et al. Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell Rep. 2022 Feb 8;38 (6) :110343.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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