Ac-Ile-Glu-Thr-Asp-pNA
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity[1].
Product Specifications
CAS Number
219138-21-3
UNSPSC
12352209
Target
Caspase
Type
Peptides
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ac-ile-glu-thr-asp-pna.html
Purity
99.90
Solubility
1 M NaOH : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 0.98 mg/mL (adjust pH to 12 with 1 M NaOH)
Smiles
O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O)[C@H](CCC(O)=O)NC([C@@H](NC(C)=O)[C@@H](C)CC)=O
Molecular Formula
C27H38N6O12
Molecular Weight
638.62
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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