AN3661

AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3) . AN3661 inhibits Plasmodium falciparum laboratory-adapted strains (mean IC50=32 nM), Ugandan field isolates (mean ex vivo IC50=64 nM), and murine P. berghei and P. falciparum infections[1].

Product Specifications

CAS Number

[1268335-33-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/an3661.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)CCC1=C(B(O)OC2)C2=CC=C1

Molecular Formula

C10H11BO4

Molecular Weight

206.00

Precautions

H302, H315, H319, H335

References & Citations

[1]Sonoiki E, et al. A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat Commun. 2017;8:14574. Published 2017 Mar 6.