CD38 inhibitor 1

CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC50s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38[1].

Product Specifications

CAS Number

[1700637-55-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CD38

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cd38-inhibitor-1.html

Purity

99.83

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1

Molecular Formula

C22H27N3O3S

Molecular Weight

413.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Haffner CD, et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin (az) olin (on) es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58 (8) :3548-71.|[2]Tarragó MG, Chini CCS, Kanamori KS, et al. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline. Cell Metab. 2018;27 (5) :1081-1095.e10.