CD38 inhibitor 1
CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC50s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38[1].
Product Specifications
CAS Number
[1700637-55-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CD38
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cd38-inhibitor-1.html
Purity
99.83
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1
Molecular Formula
C22H27N3O3S
Molecular Weight
413.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Haffner CD, et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin (az) olin (on) es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58 (8) :3548-71.|[2]Tarragó MG, Chini CCS, Kanamori KS, et al. A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline. Cell Metab. 2018;27 (5) :1081-1095.e10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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