HOIPIN-8
HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC[1].
Product Specifications
CAS Number
2519537-70-1
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hoipin-8.html
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C1=CC=C(C2=CN(C)N=C2)C=C1/C=C/C(C3=C(F)C=C(C4=CNN=C4)C=C3F)=O
Molecular Formula
C23H15F2N4NaO3
Molecular Weight
456.38
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
![N acetylglucosamine kinase (NAGK) Mouse Monoclonal Antibody [Clone ID: AT4D12]](https://cdn.genprice.uk/products/937/68dd189e061270361e8fd6c4/imageurl/am50019pu-s.webp)
N acetylglucosamine kinase (NAGK) Mouse Monoclonal Antibody [Clone ID: AT4D12]
![Rbm15 Mouse Monoclonal Antibody [A10H4]](https://cdn.genprice.uk/products/992/68dd1c8b061270361ea8164e/imageurl/ha601347.webp)
Claudin 2 (CLDN2) (NM_001171092) Human Over-expression Lysate
MLH1 (MutL Homolog 1) (MLH1/1324), CF488A conjugate, 0.1mg/mL
alpha 1 Antitrypsin (SERPINA1) (NM_001002236) Human Over-expression Lysate
