Topoisomerase I inhibitor 17
Selected Variant
HY-168739
Size: 1 Each
Topoisomerase I inhibitor 17 (Compound 7h) is a Topoisomerase I (Top1) inhibitor. Topoisomerase I inhibitor 17 reduces DDX5 and reverses the locking of Top1 activity by DDX5. Topoisomerase I inhibitor 17 induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. Topoisomerase I inhibitor 17 induces Apoptosis (reduces antiapoptotic proteins XIAP, Bcl-2, Survivin and up-regulates pro-apoptotic proteins Bax, γH2AX) . Topoisomerase I inhibitor 17 also blocks the progression of the G2/M checkpoint and induces cell cycle arrest. Topoisomerase I inhibitor 17 significantly inhibits colony formation and cell migration in colorectal cancer cells. Topoisomerase I inhibitor 17 effectively reduces tumors in human PDX tumor mice[1].
Product Specifications
CAS Number
2413582-45-1
UNSPSC
12352101
Target
Apoptosis; Bcl-2 Family; DNA/RNA Synthesis; IAP; Reactive Oxygen Species (ROS) ; Survivin; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-i-inhibitor-17.html
Smiles
FC(C=CC(C1=C2C(C(N3C2)=CC([C@@](CC)4O)=C(C3=O)COC4=O)=NC5=CC6=C(C=C51)OCO6)=C7)=C7OC
Molecular Formula
C28H21FN2O7
Molecular Weight
516.47
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Bax; Bcl-2; Topo I; XIAP
Price
Frequently Asked Questions
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