Verubulin (hydrochloride)

Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types[1][2].

Product Specifications

CAS Number

[917369-31-4]

Product Name Alternative

MPC-6827 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/verubulin-hydrochloride.html

Purity

98.71

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=NC(N(C2=CC=C(OC)C=C2)C)=C3C=CC=CC3=N1.Cl

Molecular Formula

C17H18ClN3O

Molecular Weight

315.80

Precautions

H302, H315, H319, H335

References & Citations

[1]Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67 (12) :5865-71.|[2]Sirisoma N, et al. Discovery of N- (4-methoxyphenyl) -N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J Med Chem. 2009 Apr 23;52 (8) :2341-51.